The Executive Board is appointed by the Institute Council, with the exception of the Director General, who is elected by Switzerland's Federal Council.

• Catherine Chammartin, Director General
• Felix Addor, Deputy Director General, General Counsel of the IPI and Head of Legal & International Affairs Division
• Marcus Ehnle, Vice Director General and Head of Patent Division
• Jürgen Horwath, Vice Director General and Head of the Technology & Infrastructure Services Division
• Eric Meier, Vice Director General and Head of Trade Mark & Design Division